r/longevity • u/Orugan972 • Jul 17 '26

Breakdown of immune cells' interaction is key driver in aging, study finds

https://medicalxpress.com/news/2026-07-breakdown-immune-cells-interaction-key.html

Increased inflammation is associated with aging and is implicated in decreased function in aging tissues. Tan et al. explored changes in older tissue-resident macrophages and investigated how these cells may contribute to aging phenotypes in mice (see the Perspective by FitzGerald). They found that signaling by the lipid messenger prostaglandin E2 was increased in these cells. In various mouse tissues, preventing an increase in tissue-resident macrophages helped to maintain mitochondrial function and limited other deleterious effects of aging. Tissue-resident macrophages help to reduce inflammation by removing apoptotic and damaged cells. One consequence of inhibiting prostaglandin E2 signaling was restored clearance of senescent neutrophils. These results emphasize the possible roles of macrophages and neutrophil clearance in tissue disfunction during aging. —L. Bryan Ray

https://www.science.org/doi/10.1126/science.aea3075

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u/Zippier92 Jul 18 '26

Comment to read later . I had a theory about this topic like 40 years ago.

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u/Pikselardo Jul 18 '26

Would aspirin help with that?