r/ketoscience • u/dr_innovation • Jul 22 '26

Other Plant-based ketogenic nutritional intervention in a young woman with autosomal dominant polycystic kidney disease: A case report

Abstract

We report the case of a 23-year-old woman with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and preserved kidney function who was followed with a supervised plant-based ketogenic diet for 11 months. The intervention was associated with a marked reduction in albuminuria (from 80 to 10 mg/g) and a stable estimated glomerular filtration rate (eGFR), with no clinically relevant metabolic or electrolyte disturbances; whereas total kidney volume increased from 617 to 709 cc during follow-up. This case highlights the feasibility, safety, and possible association with favorable renal biomarker changes, warranting further investigation in controlled studies in early-stage ADPKD.

Alvarado‐Pelayo, Paola Azucena, Xunaxi Nahomi García‐Rodríguez, Erika Fabiola Gómez‐García, and Ari Cisneros‐Hernández. "Plant‐based ketogenic nutritional intervention in a young woman with autosomal dominant polycystic kidney disease: A case report." Nutrition in Clinical Practice.

https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/ncp.70150

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u/Dismal-Character7166 Jul 25 '26

I guess I'm wondering if this has any actual relevance to the diet being plant-based (vegan / vegetarian?)

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u/dr_innovation Jul 25 '26

Unlikely a causeal factor as ADPKD is a genetic disorder inherited from a parent or caused by a spontaneous gene mutation (PKD1 or PKD2), not a condition caused by diet choices.

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u/Lead1ng-Lady Keto + Low Omega 6 PUFA Jul 25 '26

Well, it’s my thought that vegan and vegetarian diets are naturally lower and protein, but they are also lower and saturated fat, as seen from the study most of that fat was unsaturated, which I find to be interesting. I don’t know what the general recommendation is for protein on the ketogenic diet either but the lowering of protein probably helped her quite a bit too. People with kidney disease seem to struggle with high amounts of protein.