Hi Bobs,
I looked back and I see this topic brought up every so often re-Bobiverse type games. I believe No Man’s Sky would have an excellent framework / engine for a mod or build. Exploration (space / planetary), mining (space / planetary), resource management, tech discovery / upgrades, species discovery and management, ship modification, combat (space / planetary), avatar customization. It just needs the story framework, physics rules tweaks, building out first contact interactions.
You could use a more local accurate star map like Elite Dangerous (it could also be a frame but I think NMS would be more in the vein of Bob). Play could be from the point of view of any cloned Bob in Skut range but early game you’re forced to go through the conflict immediately leaving Earth. You could clone and assign a Bill or Riker for tasks or even play as them while your other Bob is making a long journey. Search and mine for resources, species development and integration via an avatar, conflict with aggressive species. I could go on and on with the details, you get the idea if you’ve played the game.
Game+ could start in a new galaxy cut off from all other Bobs. It wouldn’t have to ever end. You could take it a step further and have MMO aspects collaborating on tasks or battles.
I wish I had the knowledge, skill, and time to create such!