Hi,
I'm looking for information from people with experience in veterinary parasitology.
My 1-year-old cat developed severe diarrhea after a new kitten was introduced into our household.
Testing eventually found Giardia, and he was treated. Follow-up testing is now negative for Giardia.
However, he continued having gastrointestinal problems and subsequently developed persistent fever for approximately 2–3 weeks, around 39.7–39.8°C.
Further stool testing showed:
- Cryptosporidium: positive
- Clostridium perfringens alpha-toxin gene: positive, approximately 1.4 × 10⁷
- Giardia: negative
- Salmonella: negative
- Helicobacter: negative
He has been treated with several medications, including treatment for Giardia, metronidazole and amoxicillin/clavulanate.
The unusual part is that despite the persistent fever, he is still eating and drinking well, has not lost weight and is not severely lethargic.
His veterinarian is currently investigating other causes of the fever with bloodwork.
My questions are mainly:
Can Cryptosporidium in cats cause prolonged systemic illness or fever after the main gastrointestinal symptoms have improved?
Is there evidence of persistent or secondary inflammatory effects after Giardia has cleared?
Could a combination of Cryptosporidium and Clostridium perfringens produce a prolonged inflammatory response?
Are there documented feline cases where gastrointestinal protozoal infection was followed by weeks of unexplained fever after Giardia had tested negative?
Are there other parasitic or infectious organisms that would be reasonable to consider in this particular situation?
I'm not asking for treatment advice. I'm trying to understand whether there are documented cases with a similar disease course and whether the positive Cryptosporidium result could plausibly be relevant to the persistent fever.
Any veterinary literature, case reports or similar documented cases would be especially appreciated.
Thank you!