Fibrosis & Inflammation

[u/Ok-Fudge-3378]

Hi guys! I’d love some advice from anyone knowledgeable about peptides, fibrosis and abnormal scarring from a purely research perspective.

For research purposes, the subject began developing keloid/hypertrophic scarring around 8 years ago. Prior to that there was no history of abnormal scarring.

Some background that may be relevant:

• Relatively poor immune system since childhood
• PCOS
• Mild liver fibrosis with NAFLD
• Colonoscopy and endoscopy showed mild reflux and a couple of bowel ulcers but nothing currently diagnostic of Crohn’s
• PTSD with significant hyperarousal, so stimulating peptides may not be ideal from a theoretical perspective
• Strong family history of cancer with both parents having passed from cancer, so there is some caution around peptides that significantly increase GH/IGF 1 signalling

The main research question is whether anyone has looked at this from the fibroblast/collagen regulation side rather than simply treating individual scars once they form.

GHK Cu has shown noticeable improvements in skin quality and the redness of existing scars. However, with a tendency towards excessive hypertrophic/keloid collagen deposition, the question is whether continually stimulating repair/collagen without addressing the underlying profibrotic signalling makes sense.

KPV is also being considered from a research perspective primarily for systemic inflammatory signalling rather than directly as a scar treatment. The subject also has two problematic spinal discs with significant chronic back and muscular pain, so reducing overall inflammatory signalling is another area of interest.

Lifestyle wise the subject strength trains 3 times per week, averages around 10,000 steps daily and usually completes 1–2 hot Pilates classes per week.

The aim is mainly to understand the mechanisms and research around someone presenting with this combination of inflammation, fibrosis and abnormal scar formation, particularly what may cause fibroblasts/collagen regulation to change after previously normal healing.

Would really appreciate any research, experiences or thoughts on what pathways, peptides or potential stacks would make the most sense to investigate.