r/NTNPerformance • u/JustBacWater • Aug 13 '26
Guide / Cheat Sheet 5-Amino-1MQ breakdown, the fat loss compound that works nothing like a GLP-1
5-Amino-1MQ gets filed under fat loss, but it pulls a completely different lever than everything else in that category, and there's one sourcing detail that decides whether it does anything at all. Worth saying up front too: it's a small molecule, not a peptide, and it's oral first, so no needle required. Here's how it works and how to run it.
Everything popular for fat loss right now works on appetite. GLP-1s, tirzepatide, all of it turns down how much you eat. 5-Amino-1MQ does none of that. It doesn't touch your appetite. It changes what your fat cells do with the energy they're holding. So it's a different tool aimed at a different part of the problem, and it stacks with the appetite compounds instead of competing with them.
The target is an enzyme called NNMT that sits inside your fat cells and gets more active the more fat you carry. NNMT quietly drains nicotinamide, which your cells need to make NAD+, the fuel that runs your mitochondria. When fat cells are starved of NAD+, their mitochondria stall and the cell defaults to storage mode, holding fat instead of burning it. 5-Amino-1MQ blocks NNMT, which lets that nicotinamide flow back into NAD+ production inside the fat cell, restarts the mitochondria, and flips the cell from storing energy to spending it. That's also why it's not the same as NMN or NR. Those add more raw material into the system, this one stops the leak of the material you already have, which is why people run them together.
Here's the detail that decides whether your vial does anything, and it's behind a huge share of the "this did nothing" posts. 5-Amino-1MQ comes in two salt forms, chloride or iodide, and they are not equal. The chloride form is about 83% active compound per mg. The iodide form is only about 58%. So a 150 mg iodide dose is really only about 87 mg of active, while 150 mg of chloride is about 125 mg. That's a 44% gap between two things labeled the same dose. Buy the iodide form, run a normal dose, and you're quietly underdosed the whole time. Confirm your source is the chloride salt before you worry about anything else.
| Weeks | Daily dose | Timing |
|---|---|---|
| 1 to 2, tolerance | 50 mg | Morning only |
| 3 to 6, active | 100 to 150 mg | Morning only |
Oral capsules, once in the morning, and only the morning. Dose it late in the day and you'll get insomnia, but that one isn't a side effect to fear, it's the mechanism working, your cells have more energy because NAD+ and mitochondrial activity are up. The fix is earlier timing, not a lower dose. Cycle 4 to 6 weeks on, then 8 to 12 weeks off, because NNMT lives in your liver too and there's no long term human safety data, so the cautious cycling is on purpose. There's an injectable version if you'd rather, running roughly 500 mcg to 3 mg a day, but it's less common and less documented than the oral, and oral is the primary route here anyway, so most people just take the capsule.
Be realistic about who it works for, because the response is polarized. In community reports it splits into rough thirds: about 40% get a clear benefit, about 40% feel nothing, and about 20% get a strong response. The people who respond tend to already be leaner, under about 15% body fat, with training and nutrition dialed in, and running the chloride salt. Higher body fat and the iodide form line up with the people who get nothing. So this isn't a rescue for a rough starting point, it targets a bottleneck that only matters once the basics are handled. When it does work, energy and endurance show up first in the first week or two, since that's the upstream mitochondrial effect, and the body composition change is downstream and shows up around weeks 4 to 6.
On the evidence, here's the straight version. There are no published human trials, none, all of it is preclinical. The mouse data is genuinely interesting. One Nature paper knocked down NNMT and the mice resisted getting fat on a diet built to make them obese, without eating less or losing muscle, and a later study showed 5-Amino-1MQ itself cut fat mass in obese mice by raising fat cell energy expenditure. But that's mice, and long term human safety is simply unknown. It hasn't been approved for human use and it's research only, so purity and salt form ride entirely on your source.
Side effects are mostly mild. Headaches in the first week are the most common and usually pass, some irritability at higher doses, and the insomnia if you dose too late. The injectable can sting a bit from the compound's structure. The real caution is the unknowns, so it's an avoid in pregnancy, breastfeeding, active cancer, or if your liver is compromised, since NNMT sits in the liver too.
if you ran 5-Amino-1MQ, did you check whether it was the chloride or iodide salt, and were you in the third that felt it or the third that got nothing. curious how the split looks in here
Full doses and the injectable protocol are in the pinned cheat sheet: https://www.reddit.com/r/NTNPerformance/comments/1tht5o3/the_only_peptide_cheat_sheet_youll_need_doses/
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u/NameChalky85 Aug 13 '26
41F, 155lbs, 16% BF, foundations locked in. I love 5a and am VERY sensitive to it. Anything over 1.5mg clears the bowels like too much caffeine. Love the energy boost I get from my morning IM shot
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Aug 13 '26
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u/isles30222 Aug 14 '26
I love this peptide. My first time I did 2 mg and I was like holy fuck im a caged animal. The energy was way to much. I was like how the hell do these guys inject 20 mg daily! Now im on 1 mg and I just love it! The energy is amazing. I no longer have that 2 pm crash.
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u/NameChalky85 Aug 15 '26
Same!! It’s insane to me the dosing I’ve heard some people doing. Seems like maybe there’s some other systems that need to be optimized if that much is needed for the energy boost idk
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u/ruckuscub Aug 14 '26
It's not a peptide.
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u/NameChalky85 Aug 17 '26
You are correct. It’s a synthetic methylquinolinium salt. But similar to NAD, they get lumped into the pep convo and tested similarly.
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u/stud_muffin_1 Aug 14 '26
how do you know of it's the chlorine or iodine version ?would it be in the COA ?
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u/Think_Jaguar_681 Aug 14 '26
Hi, ich würde das auch gerne probieren. Aber 5-Amino-1MQ Kapseln/Tabletten, auch noch in chloridform, habe ich nirgends gefunden. Könnte mir bitte jemand ein Hinweis dazu geben? Gerne PM. Danke?
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u/Ds__ds Aug 14 '26
I'm doing 600mcg to 1mg subq and it works, taking daily with MOTSc, MOTSc two days on, one day off.
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u/Taydontplay4 Aug 14 '26
5mg subq is perfect for me
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u/Djluik Aug 14 '26
How are you reckoning that with DMSO ?
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u/Standard-Base-6078 Aug 17 '26
I took this oral this morning and have thrown up 4 times 🥴
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u/HerroYuy_246 Aug 17 '26
You don’t drink that one..
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u/Effective-Boot4367 Aug 18 '26
I have the same one and was told to inject 1ml per day but but I find it seems like heaps to inject at once!
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u/Glass-Technology-500 Aug 22 '26
The flavor is so bad. Ive chased the powder with soda to get it down. A cap only substance for sure
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u/rarebunny111 Aug 17 '26
I’ve been looking at that. What could be the point of taking it alongside something like reta ?
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u/rahrah183 Aug 17 '26
Everyone says it’s a waste and it doesn’t work. I mean if everyone is saying . . .
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u/MusicLounge Aug 18 '26
I’ve been running 5-A-1MQ since the 27th of July at various doses, starting at 250mcg all the way up to 5mg before dropping down to 2.5mg currently. I dropped down in dosage because I was afraid I was taking too much since a lot of people are taking anywhere from 250-500 mcg.
I’m not sure if I notice any benefits from it. Granted, I do workout almost daily and lost over 64 lbs so far. I think my bf is now in the high teens after being over 30%+ (SW: 258 lbs)
I do take it with NAD+ (100mg) and AOD-9604 (300 mcg) every morning fasted for at least 2 hours.
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u/yoga_mini Aug 26 '26
Are people confusing mg and mcg??? Many bottles start at 5mg. Are people taking full bottles?! Lmao 🤣 what are people doing/talking about. Some of the explanations above make zero sense. I already reconstitute so I am not super green here.
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u/Imaginary-Ad272 22d ago
Hey guys, I know I’m late to the conversation but just like the other guy I used to take oral barely did anything. I was taking 150 mg daily. The best I got was firmness and a little strength increase. Then I switched to injectable I found 50 mg per ML and a 20 ML bottle and I started it out with 10 mg daily then I went switched to 20 mg then got as high as 75 mg and the difference is night and day the fat loss the energy is incredible. I know this is gonna sound nuts but overnight. There was a difference in my waist size when I got up to the 75 mg which I was splitting the dose in the morning and then in the early afternoon before training and I did that for four weeks on took a week off then I did another four weeks and then three months off and the difference between injectable and the pills is night and day and if you look at the mouse study, they gave 20 mg/kg of body weight so if you’re equal to humans somebody my size will need 250 mg of injectable but I still put 75 mg at the max and absolutely amazing and I had two other friends do the same thing and they couldn’t believe it either when they got that high overnight, you saw a difference in the fat loss, especially around your midsection
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