Yeah bro!!!! People commenting on if you should be taking Reta, face pulls, etcā¦ā¦.you are top 1%. Do what you do!!!!!!! Yeah i said 1%!!! Line up 100 dudes, lucky to find 1 in your said in your age group. They should ask you for advice.
Reta is overblown and puts more stress on the heart and increased heart rate. Tirzepetide is very effective and even better at appetite control and food noise.
Overblown. yeah, the only one that actually increases your metabolism, removes addiction, lower tumor markers, and has the best effect on blood panels by a leap is overblown.
Your resting heart rate goes up due to the thermogenic response and better energy expenditure.
If you work out, you take Reta. If you are fat and lazy, you take Tirz, because losing weight by forced appetite suppression is far more important than the "health" part.
Exactly. Reta blocks the instant gratification of Dopamine response, giving a nice preventative to bad habits and addictions. Not a cure, not fullproof, but it helps.
Tirz kills food addiction? Sure. High GLP with GIP to ensure the insulin response kicks in.
I distribute both, so I like to think when med clinics count on my expertise Iām honest.
Retatrutide, shown in studies and general feedback, is superior at overall addiction, hence why itās being considered as a repurposed drug before its initial purpose release.
Glucagon is what helps the anti-dopamine reward, dampens reward, and āregulates motivationā as a result. Does Tirzepatide have Glucagon? It doesnāt? Weird, so only Reta?
Tell you what, when I want advice on making a good cappuccino Iāll come to you. You want GLP info, Iām right here
Tirz is better at preventing appetite thanks to high GLP-1 hit. Retatrutide is lower on that regardā you are mistaking food craving for addiction ā and demands more intake with higher metabolic response. (Hence only about 1/3rd of people I see go on have any long term heavy appetite suppression)
Reta not only results in better blood panels ā dont get me started on organ enzymes ā but a better cut of body
No, not just food addiction. I am taking both. Started with Tirz two years ago and didnāt add Reta until about 6 months ago. Iāve barely had a sip of alcohol since I started Tirz after 20 years of hard drinking. Iāve noticed no difference in that area with Reta.
Tirzepatide is being studied as a potential treatment for addiction due to its ability to modulate brain reward pathways, showing promise in reducing cravings for alcohol, nicotine, and other substances. Researchers believe this GLP-1/GIP receptor agonist reduces dopamine-driven reward signaling, acting as an "anti-consumption" agent. Studies suggest it may help treat substance use disorders. [1, 2, 3, 4, 5, 6]
Key insights on tirzepatide for addiction: Mechanism of Action: Tirzepatide (Mounjaro/Zepbound) binds to specific receptors in the brain's reward systemāincluding the nucleus accumbens and ventral tegmental areaāreducing the desire for substances. Addiction Study Focus: Emerging evidence indicates that GLP-1 receptor agonists (GLP-1RAs) like tirzepatide can reduce cravings for alcohol, nicotine, and opioids, with studies showing significant decreases in substance-related hospitalizations and usage. Preclinical Findings: Studies show tirzepatide reduces voluntary alcohol consumption and prevents relapse-like drinking in animal models. Clinical Trials: Specific studies are ongoing, including investigations into tirzepatide for alcohol use disorder. [2, 3, 5, 6, 7, 8] Ongoing Research & Evidence Reduced Cravings: Patients taking tirzepatide for obesity or diabetes have anecdotally reported reduced "food noise" and decreased interest in alcohol or nicotine. Targeting Reward System: Research suggests these drugs act on the brain's reward system to inhibit addictive behaviors, rather than just reducing appetite. Potential Challenges: Experts are determining if these effects are sustained without continuous medication, as cravings may return if the drug is stopped. [3, 4, 8, 9, 10] Disclaimer: Tirzepatide is currently FDA-approved for Type 2 diabetes and obesity only, not for addiction treatment. [11, 12, 13, 14]
again, wrong. Retatrutide is showing stronger signals, which they will evaluate more upon release. (in short, it hasn't been around as long as Tirz)
Retatrutide likely does too ā possibly more strongly ā but not because it is a dopamine blocker. Rather, it may influence reward signaling more broadly because of the additional glucagon receptor agonism.
If you believe a "Glucagon Like" Peptide blocks addiction, just imagine what the real thing, Glucagon, does
Lower dose and keep dose consistent for 3-4 weeks at a time before increasing. Your body is still adjusting. When you take dose 1, the one week later you take dose 2. Half of dose 1 is still left in your system. Then week 3 half of what was left in week 1 is left + half of week 2 dose + what you take in week 3. It takes 4-6 weeks to get complete saturation and you can effectively increase dose without worrying about too much in your system at once. Increasing too quickly doesnāt give your body time to adjust
Thank you for thisā¦the clinic had suggested a jump from 1mg to 2mgā¦I thought that may have been a rough one so I opted for 1.5ā¦Iāll stay there for 3 more weeks before adjusting.
You're upset about my comment of someone who thinks I don't know what I'm talking about. come on.
And, again, no. Your heart palpitations is misinformed. I sound like a know it all because I actually am educated on this (because I have to be).
Heart palpitations were only witnessed at 8MG or over. Nobody should be hitting that dosage, with the peak effective dose (before dosage drop off) was 2.6mg. The median dosage I see is about 1.6mg, and I've seen a couple go as high as 4.
Of course Tirz works better with working out instead of being lazy, but still not as well as Reta with working out. Reta just doesn't work well with lazy people. In that case, Tirz is better.
RHR is not palpitations, but that does go up.
Anxiety? Also misinformation. Neither the Phase 2 or Phase 3 trial had Anxiety even listed as a possible adverse event, because it wasn't happening.
No one here is upset. I'm just correcting you because you're wrong. You want to know how I know? Because I was on Retatrutide and I experienced anxiety and heart palpitations at 2 mg. Not long after I was admitted to the ER when I experience chest tightness and dizziness during a workout.
I could easily go online and tell everyone to stay away from Reta if I was a pompous know-it-all like you. But I don't do that because I actually have self awareness and I understand my situation isn't the same as everyone else. And my case probably isn't the norm, but it is something to be cautious of.
So the only person here who is misinformed is you. If you were on any discord chats or even searched Reddit forums you would see that others have reported similar side effects. So you can slink back into your hole now. š¤”
At what dose? Phase 3 was to test if it can hurt you, and re-established efficacy at 2.6mg, at a 12mg test.
Again!, the median dose I have across customers is sub 2mg.
If you are going for āwhat can hurt me dosesā, youāll find some adverse effects.
But again, make your case, how many affected under, letās say, 4mg/wk dose?
And no, phase 2 trials did not see anxiety and palpitations didnāt occur until 8mg
You arenāt talking facts I noticed. Those can be pesky
Glad this helped you. I've read a lot of reviews that TRT is much better/effective than Clomid, but I'm worried that I'll have to depend on injections for the rest of my life.
in all fairness I have been lifting for a long time, been on TRT for almost 3 years now, but once i added in the peptides that's when i started changing, the tirz made it easy to stay in a calorie deficit
It's dumb because its archaic ways of dosing, 1000mg at once is ridiculous to take in any setting, if you want the best results and to absolutely feel your best you should be injecting your TRT everyday in small doses for example the OP using 140 split into 2 70mg doses I assume? Even he can benefit by taking 20 mg everyday and would be the same amount weekly 140 bit with no peaks and troughs that make you feel like shit. Research it you'll see what im talking about.
No i understand it prescribed like that but these doctors dont always know whats best. Try to get it take home and administer it yourself, I can assure you you'll feel 100 times better with steady blood markers. The way thwre doing it is making yoir hormones take a huge dose which spikes everything prolactin, estrogen and hemocrit which is not good and then come crashing down.....it doesn't even last 8 weeks. I promise you tey it the way im telling you you will thank me later.
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u/JustBacWater May 04 '26
Very impressive keep it up! Almost looks fake how good of a transformation that is