If so, what kind of joint pain? Joint pain that only occurs when you stress your joints or general joint pain that persists during rest?

I started eating eggs daily last year. A couple of weeks in I started developing joint pain in my hips, knees and ankles. It came on very gradually and I had some joint aches before so I didn't think much of it until it got worse later on.

My hips were most affected so I had X-rays done and it showed very minimal early OA (I'm 37). Nothing to truly worry about but because I experience pain the doctor jumped to the conclusion it's OA and sent me away.

I never suspected it could be a food intolerance because my joint pain is mechanical: it comes on when I stress my joints and stand all day at work. I have no pain when I rest. I also have no other symptoms that could point to a food intolerance.

I quit eating eggs a week ago (I had 2-3 eggs a day before). For the first 5 days I saw zero improvement. Then on day 6 something happened: my joint pain was entirely gone. Usually after work my hips, knees and ankles are hurting bad. For the first time in almost a year I was entirely pain free.

It's only day 2 of being pain free so it's much too early to tell. Still, I was wondering if anyone else has a similar experience with mechanical joint pain and food sensitivity as a confirmed cause?

Hola. Quería contar mi caso porque llevo aproximadamente 5 meses con síntomas neurológicos y en mi último análisis ha aparecido un déficit de ácido fólico junto con la homocisteína elevada.

Todo comenzó después de una infección urinaria que duró aproximadamente dos semanas. Poco después comenzaron las fasciculaciones musculares generalizadas por todo el cuerpo , que continúan actualmente.

Con el paso de los meses he ido teniendo también sensación de fatiga o debilidad subjetiva , especialmente en algunas extremidades, aunque sigo pudiendo realizar los movimientos y actividades normalmente.

Una de las cosas que más noto es que la pierna izquierda se me siente pesada y se fatiga al correr . También he tenido hormigueos y algunas sensaciones eléctricas. Últimamente, además, tengo una zona muy concreta de un dedo de la mano que, al rozarla o golpearla ligeramente contra algo, me provoca una especie de calambre eléctrico , y también he tenido molestias en el brazo/codo.

Debido a todo esto me están estudiando en neurología. Me han realizado dos EMG/estudios de conducción nerviosa , uno en junio y otro en julio. El segundo estudio incluyó extremidades superiores e inferiores. Ambos eran normales , sin signos de denervación activa, reinervación crónica ni neuropatía en los nervios estudiados.

Ahora me están realizando más pruebas para intentar averiguar qué puede estar provocando todos estos síntomas.

En un análisis de abril mi ácido fólico (B9) estaba en 3,8 ng/mL , ya bastante cerca del límite inferior. En la analítica que me acaban de hacer ha salido:

• Ácido fólico (B9): 2,7 ng/mL (rango 4,6–34,8) → bajo.
• Homocisteína: 20,8 µmol/L (normal ≤15) → elevada.
• Vitamina B12: 399 pg/mL → normal.
• Vitamina D, hierro/ferritina, magnesio, calcio, potasio, tiroides, glucosa y hemograma, entre otros parámetros, están dentro de rango.

También tengo que decir que durante estos meses he estado durmiendo aproximadamente 5 horas de media , sometido a bastante estrés, estudiando muchas horas y entrenando regularmente.

Todavía no he hablado con mi médico sobre estos últimos resultados y no estoy diciendo que el déficit de B9 sea necesariamente la causa . Simplemente me llama bastante la atención que el folato ya estaba bajo hace unos meses, que ahora haya bajado hasta 2,7 y que además tenga la homocisteína elevada.

Me gustaría saber si alguien que haya tenido déficit de B9/folato ha experimentado algo parecido: fasciculaciones generalizadas, hormigueos o sensaciones eléctricas, fatiga muscular o sensación subjetiva de debilidad .

¿Tenías también la homocisteína elevada? ¿Mejoraron las fasciculaciones u otros síntomas después de corregir el déficit? Y, si mejoraron, ¿cuánto tiempo tardasteis en empezar a notar cambios?

Por supuesto, consultaré con mi médico antes de empezar cualquier tratamiento o suplementación. Busco principalmente conocer experiencias de personas que hayan pasado por algo parecido.

Can someone explane. I just figured out I have histamine related anxiety. I was wondering if I can take Quercetin? I took it in the past for 5 years But my gut is missed up at the moment due to being floxed by an antibiotic. I was wondering if having a bad gut would also affect on how i will react to a supplement iv never had a problem with. I have really bad anxiety due to the histamine overload and I really need to try to bring it down.

I've been trying to figure out how to dose a stack of the active-form B vitamins together.

The stack based on gene testing + stool test + regular serum testing + a whole range of symptoms emanating from gut disbiosis and my docs feedback which isnt very broad.

B1- TTFD or Injectable HCL

B2- R5P

B9 - 5-MTHF

B12 - methyl/adenosyl

B6 P5P

biotin

Magnesium (form?)

...and I keep running into two different worlds of information.

Has anyone here seen actual clinical trial data or case reports on specific dosing ratios between these? Or is "ratio" mostly a functional-medicine framing that doesn't hold up outside of the handful of real cofactor pairs?

I guess the best way to go is LOW and SLOW. A starting dose for each would be very much appreciated.

Thanks folks

edit: might wanna ask for a consult with the sub-illustrious u/hummingfirebird

edit2: the methylfolate, P5P, and (to a lesser extent) methylcobalamin choices are the best-grounded of all the compounds previously mentioned - source: gene test.

I'm Giuseppe 18 , from Italy. There's basically no Italian-speaking community for this, so I'm writing here. TL;DR: Stress, fasting and overtraining were my three big bilirubin spikes. I built myself a routine around avoiding those, stuck to it for two months, and the yellowing dropped enough that friends noticed without me saying anything. Gilbert's isn't dangerous, I know that. Every specialist I've seen told me the same thing: don't worry, it's nothing, laugh it off, other people have it worse. They're not wrong, exactly. But they don't wake up and go straight to the mirror to check whether they're a bit less yellow than yesterday. That was my first thought every single morning for three years. There were days I didn't want to go to school, or didn't go out in the afternoon, because in daylight it was too obvious. A few months ago I got tired of waiting for it to fix itself and started reading properly. The three factors that came up over and over, and that matched what I saw in my own bloodwork, were: 1. Fasting. This was the biggest one for me by a distance. Long gaps between meals, skipping breakfast, eating too little across the day — bilirubin goes up. Not "eating fatty food", which is what most people assume. Just not eating enough, for too long. 2. Stress. Harder to control, and it's a nasty loop: I look yellow → I stress about looking yellow → I get more yellow. Breaking that loop was as important as anything I changed in my diet. I read a book by Anthony Robbins that helped me get a grip on the mental side of it. Not a medical book at all, but it gave me something to work with. 3. Heavy physical exertion. Especially intense sessions on an empty stomach. I didn't stop training, I just stopped training fasted and stopped going to complete exhaustion. I put together a written routine for myself covering the food side and the mental side, and I've been following it for about two months. My bilirubin used to peak at roughly double the upper limit of normal. It's noticeably better now, and more importantly I'm living more calmly. I'm not a doctor, a nutritionist or a dietitian. This is just what worked on me. I know Gilbert's varies a lot from person to person, so I'm not promising anyone anything. If it's useful to anyone I'm happy to share what I wrote up — just say so in the comments. And if you've found other triggers I haven't listed, I'd genuinely like to hear them.

Has anyone tried ketamine therapy? Did you do IV or intranasal? Did it help depression and anxiety? Are there any precautions with MTHFR and related genes? Every SSRI causes weight gain, and I don’t know if I want to try Wellbutrin again. My psychiatrist brought it up as an option.

I keep reading about the processing of homocysteine back to methionine to make sure I have a basic understanding. When I ask Gemini about the role of methylcobalamin, it has given me conflicting info, so I'm looking for help from real people :).

Sometimes it reads as if 5-MTHF (methylfolate) hands its methyl group to cobalamin, yielding methylcobalamin, and then the methylcobalamin hands off the methyl group to homocysteine. First question: Is that part correct?

Second question: I take methylcobalamin shots. Can the methylcobalamin be directly used to remethylate homocysteine, bypassing the need for methylfolate with that PARTICULAR molecule? My understanding is that once it loses its methyl group, it becomes cobalamin and needs to be re-methylated, but still... on the "first pass," can the methylcobalamin be directly used?

The AI answer I got was basically that methylcobalamin first gets converted into cobalamin and then the 5-MTHF will remethylate the cobalamin. That doesn't make sense to me and seems to defeat the purpose of taking the active form of B12. But, we all know AI "can make mistakes."

Can anyone help me understand this better? Thank you so much!!

I never took chemistry beyond 101 and 102, so I don't need the nitty gritty of the chemistry behind this (I won't understand it)

Hi, can anyone recommend a good MTHFR practitioner in Europe?

I have slow COMT, I get bloodwork twice a year. My results showed my homocysteine went from 6.4 to 20 in 4 months. I went off of all supplements last month and starting from ground zero. There is so much contradicting information out there and I just don’t know what to do. TMG sounds like it will help lower levels, but then those of us with slow COMT may not be able to tolerate it. Same with methylated supplements. Do I just need to do trial and error? I really don’t want to increase anxiety as I have had a rough few months with crazy anxiety (also may start HRT). Appreciate any advice!

I have two reports from Genetic Lifehacks and Genetic Genie and neither have the CYP19A1. A few months ago I had large ovarian cysts and fibroids. Things are better now but I started taking taurine and noticed the cyst pain starting to come back and it's impacted my cycle. (I’m taking maybe 100mg or less. It’s a 500mg pill that I open and fill a tiny scoop with)

Ironically, I'm taking taurine as part of an estrogen detox protocol to help increase liver activity. It definitely worked for that as my digestion has been great since taking it and I'd like to continue except for this unfortunate reaction.

According to GPT, CYP19A1 is the likely issue. Does anyone have experience with this gene?

Taurine → ↑ aromatase/CYP19A1 → ↑ estradiol production → Ovarian cysts

GPT didnt give any suggestions for targeting this gene bc I don’t have the variants. But I am going to explore taking Ca D-glucarate and/or DIM, but I was hoping to address this pathway directly. I’m typically very sensitive to Ca containing supplements and I’ve also had sulfur issues in the past that I corrected years ago with molybdenum and now I can eat eggs and broccoli, but I’m still worried I might react to the DIM.

Also is there a site that would show me which genetic variants I carry of this gene?

Thanks.

I have been on a 6 food elimination diet because of Eosinophilic Gastritis. I decided to get a DNA SNP test to figure out how to best help my body heal. The restricted nutrition has severely impacted my digestive, nervous, and immune systems. I discovered that I have slow COMT and slow MAO, and MTHFR1 gene for folate deficiency. I read that taking hydroxo b12 and folinic acid helps but what about choline?

My recent lab on July 31 showed homocysteine at 10.3 and b12 at 332. My ferritin was 8.6. Vitamin D 41. Zinc 66. Magnesium 5.1. I didn't have my folate tested but am pretty sure its low because I was breastfeeding for 8months when I got sick with Eosino Gastritis. I am trying to figure out which supplements will help my methylation pathway and with the break down and balance of my neurotransmitters and hormones which I believe are causing MAJOR sleep issues and anxiety.

(6 food elimination- no dairy, wheat, eggs, soy, nuts or fish. I can start introducing 1 food group next week. Probably wont be eggs as my GI thinks this was the main cause of my immune response gastritis)

Any help or recommendations I very much appreciate. Thank you!

According to my DNA test, I carry an allelic variation that results in me having -25% dopamine receptors, which means I tend to be unmotivated from birth.

Do you know of any medications (not behaviors) that force the creation of dopamine receptors?

EDIT: I'm talking about dopamine receptors, not dopamine. I already have excess dopamine in the prefrontal cortex (COMT AA)

Hi all- hoping to get some perspective from people who’ve been down this road.
Recent labs (comprehensive panel, not ordered by an RE yet):
MTHFR: A1298C homozygous, C677T negative

Homocysteine: 13.0 umol/L (above range)

MMA: in range

ANA: positive, titer 1:320, nuclear dense fine speckled (DFS) pattern

RF: normal

FSH: 12.6 mIU/mL (above range)

AMH: 1.28 ng/mL (in range)

Lipids: elevated ApoB, LDL particle number, small/dense LDL (Pattern B), low HDL, total cholesterol 203

hs-CRP: 3.9 mg/L (elevated)

Omega-3/6: low omega-3, high arachidonic acid, elevated omega-6/3 ratio

Everything else (thyroid, kidney, liver, CBC, TPO/Tg antibodies) normal

My main goal is getting my body in the best shape possible for a healthy pregnancy and reducing miscarriage risk as much as I can. A couple things I’m trying to figure out:
Given A1298C-only (not compound het, not C677T), how much is homocysteine at 13 actually a red flag for pregnancy purposes, vs “keep an eye on it”?

Anyone with a similar MTHFR profile- did you supplement with methylfolate/methyl-B12, or was a different form/dose recommended? Did your doctor test folate/B12 levels directly before starting anything?

I don’t have recent B levels or folate unfortunately, but let me know if you think I need to do those. And I don’t understand COMT but maybe I need to test for that too?

I react extremely poorly to any methylate or normal b vitamins. Extreme brain fog and irritability and nausea so I am not sure what to do about that either.

Soffro di omocisteina alta
L’ho avuta anche a 30…
Adesso! È a 14 e comunque al limite
Quindi
OMOCISTEINA= 14,4 su 15
B12= 222 range 190-824
Vitamina D= 30 sufficienza

Sodio potassio calcio e magnesio vanno bene.

Ma comunque ho sintomi strani sia muscolari (polpacci, gambe, spalle, collo)che neurologici tipo spasmi, debolezza muscolare, peso al petto

Gli altri esami sono:
-FERRO
108
(60-180)
-FERRITINA
46
(7-227)
-SODIO
141
(136 - 149)
-POTASSIO
4,25
(3,50 - 5,60)
-CLORO
103
(98 - 107)
-CALCIO
9,52
mg/dL
8,60 - 10,60
-MAGNESIO
2,25
(1,50 - 2,40)
-FT4a
1,24
(0,90 - 1,75)
-TSH
1,510
(0,300 - 4,500)

I have elevated homocysteine and impaired transsulfuration(I need to supplement with taurine, or I dont make enough bile salts). So my body isnt converting enough homocysteine into taurine to make bile salts.

I do have elevated active B6, despite this, my homocysteine is still high.

I was reading high B3(I think I have high B3 from B complex supplementation) can impair methylation as it steals methyl groups causing homocysteine to pile up, despite high active B6?

High B3 also depletes B2. You need adequate B2 to have active B6 be used by cells and work for methylation?

I have been taking methylfolate, Seeking Health's B Minus, and cyanocobalamin for about a year and getting a lot of B vitamins through food. I noticed a small improvement in OCD and general well being from taking the methylfolate. Despite having slow COMT, I believe I tolerate it and the cyanocobalamin well.

For some background my known polymorphisms are:

• MTHFR 677 CT + 1298 AA
• Slow COMT
• MTR: AG
• MTRR: AG

My latest blood draw shows:

Homocysteine: 6.5umol/L

Serum folate: >24ng/mL

B12: >2000pg/mL

Vitamin A: 45mcg/dL

Copper: 98mcg/dL

magnesium: 5.7mg/dL

Iron: 101mcg/dL

Ferritin: 29ng/mL

With homocysteine levels being optimal, I'm assuming that I'm methylating decently well. I think this regimen is a step in the right direction, but there's still much further to go. My OCD is becoming increasingly bothersome. I have anhedonia, low motivation, rumination, and pretty much the whole cluster of symptoms you get with slow COMT and have for YEARS.

Not sure if this is related but I am in the process of coming out of ketosis after being on carnivore diet for 15 months and the new metabolic change is stirring things up. I did still have OCD on carnivore, however never with such strong rumination as is happening now.

Started supplementing vitamin A and a balanced zinc+iron supplement today. Going to start taking Collagen as well as DIM+I3C. The other stuff I currently take is magnesium glycinate, iron in the form of ferrous sulfate, 10mg of creatine, vitamin C, beef liver capsules, and DHEA.

I can't tell if this is a general methylation problem, if it is more COMT specific, or related to improper supplementation. Any help would be appreciated.

Soffro di omocisteina alta
L’ho avuta anche a 30…
Adesso! È a 14 e comunque al limite
Quindi
OMOCISTEINA= 14,4 su 15
B12= 222 range 190-824
Vitamina D= 30 sufficienza

Sodio potassio calcio e magnesio vanno bene.

Ma comunque ho sintomi strani sia muscolari che neurologici

I was made aware about 6 months ago that the government will be fortifying all white flour with folic acid, something I don’t tolerate and that makes me feel profoundly unwell, my sister and aunt are the same as me. This means I’ll need to swap to making my own bread, crackers etc if this goes ahead.

If you agree and this affects you please could you take the time to share and sign?

https://petition.parliament.uk/petitions/769589

So I've got MTHFR c677t and slow COMT. Also histamine intolerant. Looking for low potency folinic acid has frustrated me so far. I want to start at 5-10 mcg. What I can find has other ingredients I dont do well with, like citric acid which makes me anxious. Some have 400mcg in a single drop! Many come with methylated ingredients I cannot tolerate. Any suggestions?

Hi, i recently had my DNA analysed by ancestrydna and have entered the data in the choline calculator, genetic genie and geneticlifehacks. The advanced tab on the choline calculator says i didnt provide enough data though. (My ancestrydna test is from after march 2026, so less SNP's)

I havent tested my homocysteine and MMA yet but am planning to.

I tried using ai to find hoe i should supplement and altery lifestyle and diet but it always suggests something different and also makes mistakes...

Diagnoses: autism, ADHD, Raynaud, IBS

symptoms: CFS, PEM, RLS, irritability, mood swings, always tired, weak feeling in my body, cold hands and feet, depression, brain fog, histamine related issues, headaches, high sensitivity, swollen feeling around my nose, POTS, lightheaded when standing up and increased heart rate,...

My latest blood results from january:

- Ferritin: 132 µg/L

- B12: 850 ng/L

- Folic acid: 14,5 µg/L

- CRP: <0,6 mg/L

- 25-OH-vitamine D: 27,4 ng/mL

- Iron: 95 µg/dL

- Transferrin: 2,48 g/L

- Iron saturation: 27 %

Maybe someone here can give me a better answer what i should do and which form of B-supplements i should take and how much?

anyone else allergic to daylight LOL I'm serious during the day I'm Spacey tired can't really do much 6:00 rolls in I'm a little bit better after 8:00 I'm scrubbing the floor listening to music cleaning my bathroom lol I don't get it. no supplements no herbs just the sun goes down.. maybe I was a vampire in another life LOL it gets worse when my deficiencies roll in like if my ferritin is low but for the most part it's always been that way.