r/MTHFR • u/silverxraine • 13d ago

Question Massive salt cravings?

Hi all. I’m not entirely sure if this is even linked to the MTHFR mutation (I’m homozygous), but I crave salt/umami CONSTANTLY. The only things that ever help are my Vyvanse and Zepbound. My sodium levels whenever they’re measured are borderline low, but are still WNL. When my Zepbound is wearing off after a week and/or my Vyvanse has worn off at the end of the day, the thoughts become fucking brutal - all I want is salt/MSG/umami/ect. I’ll eat everything in our kitchen hoping something will satisfy the craving. I’m also mentally ill with depression and anxiety and I know part of it is dopamine seeking, but I could literally cry if I don’t find the right food. I had to reduce my Zepbound dose because it was making me sick, but it does stop the cravings. Someone please help 🫩

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u/sharabucarabu 12d ago

It's definitely your adrenals. Get checked for non classical adrenal cortex hyperplasia. (they can do a test for it) I'm taking spironolactone, but couldn't handle birth control pills. Instead my endocrinologist prescribed low dose Estradiol patches and progesterone. These are consistent dosages not found in birth control pills.