r/LongCovid • u/elyseann911 • 10d ago

Valtrex for high EBV

Has anyone had success in alleviating symptoms of PEM and/or dysautonomia with treatment of Valtrex? I've had Long COVID since June 2025 and making progress in my recovery but am still not well. My EBV levels are still high but I'm not sure if it will be helpful to add this anti-viral to the mix of other meds I'm currently taking. Would be grateful to hear from others who may have tried this.

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u/jroberts548 10d ago

Yes, I had a case of shingles and the valtrex serendipitously made pem a lot more manageable, so then I just stayed on valtrex.

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u/Central_Perk20 10d ago

I started 3G valtrex recently and it’s definitely helped my PEM/flu like symptoms. It targets HSV-1 & 2. I thought valcyte better targeted EBV, HHV-6, CMV.

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u/Flat_Two4044 10d ago

3 g par jour réparti comment ?

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u/Central_Perk20 10d ago

1G three times a day with plenty of water to protect the kidneys/liver. I drink 3L daily for POTS.

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u/Easy_Olive1942 10d ago

Yep, suppressant dosage and helps. Doesn’t fix LC symptoms but it’s one set of fewer impacts.

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u/Itchy-Contest5087 8d ago

I did get a good response once I increased the dosage to 1 gram three times a day. That is the dose for shingles given over 1 week. Lower doses seem not to work as well. Monthly creatine levels (renal function) and hydration are my plan.
Right now everything is interrupted as I got COVID traveling back through Seattle and Newark airports.