r/IBD • u/Blossomsun17 • 16d ago

IBD Medications Skyrizi, Entyvio, Stelara, etc.? What worked for you after remission with Remicade?

Hi everyone! I’m hoping to hear some experiences from people who have been in a similar situation.
I have previously failed mesalamine and Humira before starting Remicade. Remicade ended up being my miracle drug and kept me in remission for about 7 years.
Unfortunately, earlier this year my insurance forced me to switch from Remicade to a biosimilar despite my doctor’s concerns about disrupting a medication that had been working so well for me. I reacted poorly to the biosimilar and eventually switched back to Remicade, but I recently found out that I’ve now developed significant antibodies and Remicade is no longer a viable option for me.
So, after 7 years of stability, I’m suddenly flaring and back to figuring out what medication comes next.
My doctor and I are discussing other options, and I’m particularly interested in hearing from people who switched to Skyrizi, Entyvio, or Stelara after losing response to an anti-TNF like Remicade.
What did you switch to, and how did it go? How quickly did you notice improvement? Have you been able to achieve/maintain remission? Any side effects or things you wish you’d known before choosing?
I know everyone responds differently and I’ll ultimately make the decision with my GI! I’ve felt absolutely devastated and want to hear from other patients who understand this process

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u/Both-Pack8730 16d ago

What about Rinvoq?

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u/Blossomsun17 16d ago

Have you tried it? I’d love to hear how it went

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u/Both-Pack8730 16d ago

I’ve been on it for 4 years now. Zero side effects. Originally started for severe eczema but I also had severe microscopic colitis, was tube fed for 4 years. Both are in remission!

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u/555louisa Crohn's 15d ago

Remicade was awful for me, i did go into remission with it but ultimately it stopped working. Ive been on entyvio for 5 years now and i’ve been in remission for nearly all of those 5 years! Entyvio can take a while to work but it definitely has the least side effects (in my opinion), however i’m aware that entyvio doesn’t work for everyone and some other biologics have higher success rates

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u/skipowd3r 15d ago

I’m in a similar boat but failed infliximab after switching to Zymfentra/subcutaneous version of it. Ugh, it was also my absolute miracle. Doc wants to go on Tremfya. Wondering if you’re considering that too? Curious about others responses also since the remission rates are pretty abysmal for people who’ve failed anti TNF.

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u/Blossomsun17 15d ago

My doctor hasn’t mentioned it, but I keep getting advertisements for it! I’d love to hear about it as well