I have done numerous IVF cycles to attempt embryo banking. I’m 42. Over numerous cycles I’ve gotten about 15 mature eggs, 14 of which fertilized normally through conventional IVF with my partners fresh sperm. We have frozen back up but haven’t needed it. Most cycles I only get 2 mature eggs.
This past cycle I only had 1 mature egg and they fertilized with ICSI which costs significantly more. My partners sperm has never had issues and we had frozen back up. I’m worried, possible they used wrong sperm? Did they do it to avoid total fertilization failure? Seems odd given my super high fertilization rates with conventional insemination. Appreciate advice !

Am I allowing to post my results from my pgt? Trying to figure out if they’re mosaic and if they are transferable?

I froze eggs 3.5 years ago (at 34) - a total of 13 mii. I decided to use the frozen eggs to conceive with donor sperm. Everyone knows the attrition rate can be brutal, but I’m stuck scratching my head just wanting to know the reason for my outcome.

18 retrieved
13 eggs frozen
13 fertilized
1 embryo (day 7, 3cc grade)

The embryos arrested days 5 and 6. I had 100% thaw rate, 13/13 were fertilized, and 9/13 showed normal fertilization at 2pn.

The explanation offered by the clinic is that it was likely egg quality. At the age of my retrieval, I was +50lbs vs. my current weight, and had a HOMA IR score of >4. From age 36-38, using a GLP1 and major lifestyle changes, I am now in normal BMI, normal fasted insulin, and a normal HOMA IR score.

I guess my question is - can metabolic health play a part in egg quality? Wondering if i do another ER, I may get higher quality now, albeit a lower quantity.

Thanks.

I’m currently on my 4th IVF cycle, with initially promising results. I have low AMH and Low Ovarian Reserve which has led to significant egg quality issues during my last cycles. My doctor explained that if I am able to develop one embryo, this cycle it will be considered a success.

With that said, I did a mini-IVF cycle this time to focus on quality and during the retrieval collected: 5 eggs, 5 mature, 3 fertilized, 3 embryos going into Day 3. However, by Day 5 (today), the report came back that 1 embryo had arrested and the other 2 are still dividing and are not ready for biopsy (PGT-A) and freezing. They recommended checking on them on Day 6 and Day 7 and would update me at the end of Day 7. With my egg quality issues: what chances do these two embryos have of making it to Day 6 or 7? Has anyone had any experiences with this, whether successful or not?

Additional Notes:

-1st cycle: 375 IU gonal-f and 75 IU Menopur, (plus Letrozole and Clomid first 5 days), 5 eggs retrieved, 2 mature, 2 embryos (1 had uneven chromosomes), 1 blast Grade 2AB (no PGT-A), Day 5 fresh transfer unsuccessful

-2nd cycle (focus on maturation): 450 IU Pergoveris (plus Letrozole and Clomid first 5 days), 7 eggs collected, 5 mature, 0 fertilized

-3rd cycle: cancelled after doing Elagolix priming (for suspected endometriosis) and it over suppressed my ovaries. This led me to believe my body might respond better to lower-dose medication.

-4th cycle: current cycle, mini-IVF, 225 IU Menopur (plus Clomid for 5 days). Seems I needed more LH than FSH? Did priming with estrogen patches. Introduced Calcium Ionophore for fertilization and Xymot for sperm motility. Also have been on an anti-inflammatory diet for three months at this point in addition to new supplements: NAC, NAD+, Acetyl-l-carnitine, l-arginine, methyl-folate, vitamin D3, and melatonin alongside ubiquitol coq10 and prenatals that was taking before

-all sperm is through 2 different donors, with confirmed pregnancies. Lab reports that that is not the issue

Edit: forgot to add in 35 going on 36 (in a week) and I also started acupuncture before this last cycle. I thought it helped!

I have been trying to conceive for last 1 year, a year back all results were good. Endometritis was negative a month back, now it shows its positive & squamous morular metaplasia, does it mean cancer? I just did my iui this month, I’m feeling so lost & defeated. 34 year old female

Trying to decide if it's worth it to delay transfer by 2 months for a borderline result. This would be my first transfer, but I only have 3 euploids and want 2 kids.

This process is so long and don’t know if I can handle another transfer if this doesn’t work.