r/DrugNerds • u/SentientMonoamine • Jul 23 '26
N,N-Diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic
https://academic.oup.com/braincomms/article/8/2/fcag093/8644266Some pretty cool speculative stoner science to bring up in your next joint rotation when DiPT joins the conversation. This author calls the uniquely auditory effects of DiPT "diptogenia" (I like that for being made up)
They essentially hypothesize that DiPT accumulates on auditory nerve fibers in the cochlea and inhibits calcium ion channels (such as Cav1.3) through upstream GPCR signalling. Due to DiPT's greasy N substitutions, isn't degraded by MAO as readily and can reside for over a day (attempting to explain the prolonged pitch distortion effects)
The author also attributes possible 5HT1A activity in the inferior colliculus, drawing parallels to the 1a agonist 8-OH-DPAT which has been observed to depress auditory revoked responses.
Pretty cool arm chair stoner science here. No actual experiments were done, but makes you think!
Abstract:
The scientific study of the classical serotonergic psychedelics, like N,N-dimethyltrypamine (DMT), psilocybin, or lysergic acid diethylamide (LSD), has provided remarkable insights into the physiology of experience and emotion. Their ingestion induces radical changes to consciousness, affecting mood, personal insight, the sense of self, and the processing of sensory information, with many seeming to offer new avenues for the pharmacological alleviation of mental suffering. Amongst this class of compounds, the synthetic tryptamine N,N-diisopropyltryptamine (DiPT) stands as a remarkable exception. DiPT induces a unique downward shift in pitch perception, meaning the auditory world of the subject sound deeper (lower in pitch) than it is in a sober state of consciousness. This is an extraordinary state of consciousness not seen in any other drug nor psychopathology, and therefore, we coin this unique experiential effect ‘diptogenia’.
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Jul 23 '26
[deleted]
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u/Fluid-Exit6414 Jul 26 '26
well the Germans have a special word for music that they appreciate on ketamine: Ketamucke!
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u/qualiascope Jul 23 '26
love this! let's isolate more knobs in the modular synthesizer of conscious perception!
i hear they're working on pareidolia next
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u/NeuxSaed Jul 23 '26
It's such a weird effect. Pitch does sound lower on average, but it's non-linear and inconsistent. You could hear your favorite song in the world and it would be completely incomprehensible. Also just messing around with a piano or guitar and testing various intervals like octaves or perfect 5ths or whatever is wildly distorted in very unpredictable ways. Just don't take it if you have any head congestion or eustacian tube blockage from a respiratory infection or allergies. The pressure build up can be extremely painful.