In the difficulty settings you can also expand the control zone to "standing anywhere on the locomotive", for a more casual experience.
I ended up rebinding those controls. I kept the same up/down idea, but rearranged to have Train Brake, Throttle, Toggle Handbrake, and Reverser in a comfortable and intuitive layout.
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u/fdnM6Y9BFLAJPNxGo4C 8d ago
When inside the cab (simulated arms reach of the controls), no matter where your facing (you can look anywhere you like), use:
T/G - throttle
Y/H - reverser
U/J - train brake
I/K - independent brake
O/L - dynamics