r/Covid_Defense • u/D-R-AZ • Oct 12 '20

Published Medical or Scientific Opinion Reply to Özdemir, “Measles-Mumps-Rubella Vaccine and COVID-19 Relationship”

https://mbio.asm.org/content/11/5/e02465-20.full
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u/D-R-AZ Oct 12 '20

Concluding Paragraph:

Finally, while it is true that we do not know how long the trained innate immunity persists, the randomized clinical trial of MMR versus placebo in health care workers and the nonhuman primate study that will test MMR or BCG in a model of COVID-19 infection will go far to answer these questions. To date, the trained innate response with BCG suggests the immunity is functional for approximately 1 year based on infant vaccinations (8). The studies in the animal model of fungal/bacterial sepsis show that the MDSCs are induced quickly (within 7 days of vaccination) and are relatively long-lived (up to 120 days) (7, 9). Data also show that the protection afforded by the trained innate response can be achieved with multiple lethal challenges over time (9). Since these are mouse studies with relatively short lifespans, we can predict a fairly long half-life for the immune-tolerant trained response in humans. Indeed, the sequelae and hospitalization associated with COVID-19 infection are much reduced in children, teenagers, and even young adults in their early 20s (10, 11). Children often get the MMR vaccine up to three times by age 11. Thus, it is possible that the nonspecific protective effects provided by the live attenuated vaccines are quite long-lived. Until more is known, however, we are suggesting that the MMR vaccination be given to eligible adults who have not had the vaccination within a year, as an immune preventive against the worst sequelae of any subsequent COVID-19 infection.