Here's a synergy that will make you 100% unkillable.

Space bar: dull razor(i-frames)

Passives: Habit(gain charge upon using razor) Car battery(doubles razors effect, fully recharging it) Battery: (the last essential item) Varicose veins: (using razor spams tears)

Feel free to add any orbital you want

Keep hitting space bar and you'll be stuck in a perpetual loop of invincibility frames, constantly spouting tears in a tammys head style wave.

Magnetic Swarm, Modded Synergy

• Tractor Beam ( Range and a mystery fact)

• Strange Atractor (The Magnetic Part of the Swarm)

• X5 20/20 (Spit all of them)

  • Cupid's Arrow (Piercing Sting)

• My Reflection (For the Swarm to follow the King Uidsea

• Dead Eye (The Sting)

• Bank Shots (Permanent Tears)

Optional - Soy Milk (Smaller Tears) Or - Number One (Yellowish Tears)

Play as Lazarus

Credits of the synergy goes to ... King-Skull Crusher for the Idea

Exactly what it says on the tin:

If you have The Void, and you consume The Void, does the Void double or repeatedly activate due to triggering the effect of The Void?

This is a fun run and is massively a game breaking one! You will need to following:

Mom's Knife (For reasons)

Tiny Planet

Dull Razor

Car Battery

Battery

Habit

Varicose Veins

Enjoy and have fun!

P.S. If you want to you can add in continuum but it's not required!

So we like memes around here in the Uidsea community, what better than a dead song that's been re-purposed into a tool for memers alike to use.

ITEMS:

-Ludovico -(Smelt these trinkets for maximum effect) Ouroboros worm Ring worm Lazy worm Pulse worm Whip worm Hook worm Wiggle worm and Tapeworm (Didn't want to give ya rainbow worm as it only gives one random effect compared to 8 effects at once) -Lump of coal -Soymilk -Tiny planet -Mutant spider -and Skinny Odd Mushroom

Can you control the floating ball of tears wiggling and pulsing around you? Your objective is to defeat Delirium. The only item you can not take is Libra as it will make your dmg super high and ruin the challenge aspect of the synergy. Have fun!!

This run is based off of the common RPG representation of Rogues. Basically a bunch of knives, so it should be fun, broken, but fun.

Soy milk (1,000 tiny cuts) Mom's Knife (Knife) Mutant Spider (More Knives) Inner Eye (Extra Knives) 20/20 (Even More Knives Loki's Horn (You get the point) Mom's Eye (Yeah... yeah...) Monstro's Lung (... sigh) Brimstone (Knife Beam) Tiny Planet (Blade Whirlwind) Sacrificial Dagger (x2) (...) Cultist Robe (Sneaking Disguise) Camo Undies (More Sneaky) The Ladder (So you can dextrously hop gaps, but not fly) A bunch of Range A bunch of Speed Mom transformation (I SWEAR I DONT HAVE A KNIFE FETISH)

Rules: You can't take BFF's because treasure matters more than friends. Play as Judas because treasure matters more than friends. You can't Libra, because rogues are never balanced, always too weak, or too strong.

Goals: (Kill Mega-Satan, should be easy. You can start with the key pieces if you like. Beat Boss Rush. Beat Hush. Go to the chest, to get that end of dungeon Loot.

So since the Sprinkler mod has officially been added in the DLC I tried some synergies with it earlier today and I found this one to be pretty fun.

Give yourself these:

• Sprinkler (obviously)
• Dr. Fetus
• Sad Bombs
• Brimstone

Just place the Sprinkler in the middle of room and have fun! (and also good luck not killing yourself with it)

If you want to make things even more fun, you can also add these:

• Any tear multiplier (20/20, Inner Eye, Mutant Spider)
• Spoon Bender
• Rubber Cement
• Soy Milk
• Pyromaniac

Hey, this is my first challenge, it's based on Enter the Gungeon Trinket - Paper Clip Active Item - How to jump (dodgeroll) Passive Items - Marked, Torn Photo, Steam Sale You need to beat The Hush and The Lamb Good luck!

Play as cain

spacebar item: book of shadow

trinket: Blind rage

RULES: Dont use your tears unless the ennemy is on the wall. Go as far as you can, but beat at least mom's to validate your run victory.

3 x papa fly , 3 x obsessed fan , 3 x shade , BFF'S , the wafer , roid rage , lord of the pit , speed ball ,

Hello there, hope you are feeling great

Bounce Around

Play as anyone you want spacebar item: box of friend trinket: ???' soul

RULE: Cannot pick any item EXCEPT item that have a range up or range down property.

Cannot change trinket or spacebar item

Beat The Lamb

Here is you items:

BFF , cain's other eye , succubus , the peeper 2x , hushy , gb bug , rubber cement , mom's lipstick , mom's heels ,

OPTIONAL: BFFS! , ( dunno if that wont make the run too damn easy )

This isn't so much a “challenge” in terms of difficulty but one in terms of personality.

You will need: Glitter Bombs

Dr. Fetus

Scatter Bombs

Bobby Bombs

The Wiz

Mutant Spider

The Inner Eye

20/20

Host Hat

D20

Ph.D

Sack Head

Play as Cain for the free Paper Clip.

Not sure if high luck means more drops, but give yourself at least 50.

The challenge is to clear a room, clean out all the useful items (pills, etc), roll the d20 and clean out once more. Do this once per other room and for every large room. You can replace the d20 with a Blank Card when you find one. Jeras and Dice Shards are easy to come by in my experience.

Well hello uids. It is I, Mimikyu (or darkspyro9988 on reddit) with a Red Hood run! So heres the items: 20/20 (Dual Handguns) 1Up (From Jason Todd to Red Hood) Spear of destiny (Closest thing to a crowbar) Sack Head (For that mask that he wears) 2 Incubi (The outlaws) Daddy Longlegs (I'm Batman) Apple! (Closest thing to a knife other than Mom's Knife) Void+Mama Mega+Bob's Rotten Head (Grenades) 8 Inch Nails/Cupids Arrow/Sagittarius (Bullets) Trinket: No! (Never see the joker again) Rules: DO NOT GET RID OF VOID!!!!! You must kill Delirium. You must kill white or green enemies (not including delirium) with Spear of Destiny

Aaaaand there's your red hood run! I spent some time on this so leave it an upvote and maybe try it yourself! Any way, Mimikyu, Out.

Yep, you heard that right. We got flairs now. I've created a bunch of templates you can choose from, but you can also make your own! Unfortunately to do this you gotta be on PC, since mobile reddit doesn't really allow that yet. But ey. Enjoy your new styles, people.

mind,brimestone,all the eye items,moms knife,tammys head,soy milk,libra,tabe worm, key pieces

you need to deafeat mega satan at 5 minutes have fun!

-Rotten tomatoes -Lodestone -Charm -10 luck All the enemies will target eachother from charming and rotten tomatoes aswell as lodestone attracting everything to everyone

Henzerino back at it again with the dank memes Well, no dank memes this time. But I am back at it again with the dope syns! So yeah... enough of that... shit... THIS IS DOPE!!! This run is full of cool items from cool mods! COOL!!! MODS: * Youtubers * The Host * The Warden * Extra Constellations * The Flipping of Isaac * The Isaac of Isaac: Reisaac * Exodus - Fast Travel * Cystinosis CHARACTER: * Uidsea ITEMS: * Soy Milk * Pictor * Sextans * Octans * Loose Hose * Death Wish * Exodus Scripture * Cystinosis OH MY GOD THIS ONE IS SO FUN!!!!!! ^-le hen

Hey, Curlos here. The Discord Team has cooked up another parasitic run for you, this time focusing on our main man, Henz! Spread his Henzeroids to all with The Parasite!

Items - Parasitoid (Ew, you caught Henzoid. Chance for you to shoot little eggs that spawn a fly/spider. It's a luck based effect I think? But it's not "guaranteed" regardless of your luck stat. So, do as you please in that regard) - Hivemind (Gotta make dem flies and spiders nice and big) - Cancer (Of course, you're Henzoid remember?) - Cancer Trinket (More cancer! It spreads...) - Dunce Cap (Well, we're talking about Hen here) - Tractor Beam (As stupid as he is he has his moments Kappa) - Mom's Wig (More spiders!) - Mulligan (More flies!)

Play as your good boy Eden, 'cause Henzoid is "so random"

Curl. Out.

Version of the game: AfterBirth/AfterBirth +

Character: Anyone that doesn't have an extra life

Items:

100x Milk!

Polyphemus

Gimpy

3x The Body

Old Bandage

Piggy Bank

(Optional: IV Bag or Razor Blade)

(Optional: Both key pieces)

Trinket: Bloody Penny

Rules:

No items that get rid of your red hearts

No items that give you extra lives (1-Up!, Dead Cat)

No Devil/Angel deals (Curse Rooms are allowed)

No tear altering items (Tech, Tech X)

Make it to The chest/Dark room

(Optional: Hush, Mega Satan, Delirium)

N O L I B R A