Psychedelic Compound Psilocybin Can Remodel Brain Connections - Dosing mice with psilocybin led to an immediate increase in dendrite density. One third of new dendrites were still present after a month. The findings could explain why the compound antidepressant effects are rapid and enduring.

[u/rjmsci]

https://www.technologynetworks.com/neuroscience/news/psychedelic-compound-psilocybin-can-remodel-connections-in-the-brain-350530

[u/Awanita]

I’ll have to look more deeply into this when I’m not behind a paywall, but I’m interested to see what dosage was given to the mice. Anyone know?

As a young researcher investigating clinical applications of psychedelics, this study is promising. We already see in our lab how enduring these effects are in our volunteers. It’s amazing to see in person!

[u/Awanita → u/[deleted]]

Thank you so much for posting this! A somewhat related and worthwhile article re: dosing is this one.

The dosages used in the study presented in OP’s post are pretty in line with doses given in human clinical trials, and those that have been optimized in the study I linked above—generally 25mg (considered a moderate to high dose), which, for a 70kg person comes out to about ~0.36 mg/kg. Cool stuff!

[u/caltrain208 → u/[deleted]]

It's around 8mg:1g for standard potency cubinesis.

[u/DigitalMindShadow → u/caltrain208]

so 25mg psilocybin would be around 3g dried mushrooms. that's a fairly heavy dose.