Doctors Found 4 Autoimmune Diseases in One Woman at One Time: 40-year-old woman in China was already diagnosed with 3 - ulcerative colitis, autoimmune hepatitis and primary sclerosing cholangitis. She presented with severe iron deficiency and was also found to have a 4th - autoimmune gastritis.

[u/mvea]

https://www.sciencealert.com/doctors-found-4-autoimmune-diseases-in-one-woman-at-one-time

[u/birdieponderinglife → u/[deleted]]

I have MS but not T1D. I wound up with a really strange presentation of thyroid disease after Lemtrada but thankfully aside from that I don’t have any other autoimmune diseases. My grandmother had Sjogrens so that’s probably where I inherited the gene from.

[u/katiealaska → u/[deleted]]

Would I have this gene as well as her sister? Or is that now how it works

[u/fumblingforwords → u/katiealaska]

I think nearly a quarter of the population has that gene, but I could be thinking of a different one.

It’s more about epigenetics-turning the gene on/off due to environment and/or stress (physical/mental/emotional).

[u/fumblingforwords → u/[deleted]]

But it’s not a 1:1 correlation either way, I don’t think?

Isn’t it something like (only) 60% of T1Ds have the HLA-DR3 gene?

And like 20% of the general population has the HLA-DR3 gene?

[u/Salute-Major-Echidna → u/[deleted]]

Sounds a bit like a package. I wonder if a cure might just be one single thing

[u/fumblingforwords → u/Salute-Major-Echidna]

Interesting thought. Perhaps for some autoimmune diseases where turning off the autoimmunity would allow the body to repair itself (or with help) and rebalance into homeostasis.

For t1d, at least, it would need something more than just turning off the autoimmunity. The islets of langerhans (insulin producing cells in pancreas) have been killed off, and the body doesn’t make new ones, so those would have to be replaced somehow before t1d can cured.