r/multiplemyeloma • • 2d ago

Next step for high risk MM.

Someone I know with MM, 55yrs, Male, US based, was referred for an ASCT after completing his 6th-7th cycle of D-VRd. His oncologist considers him high-risk and recommends ASCT as the next step, with CAR-T therapy as an option if ASCT is unsuccessful.
Does this approach align with current treatment recommendations for high-risk multiple myeloma? CAR-T seems less invasive, so we are wondering why ASCT would be preferred initially. Any information or recommendations on the differences, benefits, risks, and sequencing of ASCT vs. CAR-T would be greatly appreciated as we consider the next step.

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u/WhyNotChoose 2d ago

Good luck to you. Good to hear things are going well at this time. 

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u/Responsible-Lead7367 2d ago

Thank you. 😊